Foster City, CA | Full time
Job Description
The Research Associate I/II will contribute to our efforts toward discovery of monoclonal antibodies using hybridoma and single B-cell technologies from AbTherx AtlasTM Mice. The position requires a motivated individual with hands-on experience in hybridoma generation and antibody capture, a core function for AbTherx. The position will, with minimal supervision, deliver on projects against a variety of targets using all appropriate antibody discovery approaches to reach the pinnacle of antibody diversity and reactivity. This job is associated with the Antibody Discovery Group, reporting to the Director of Antibody Discovery.
About AbTherx
AbTherx is advancing medicine with revolutionary technologies that accelerate and enable therapeutic antibody discovery. Through an exclusive partnership with Gilead Sciences, AbTherx has released Atlas™ Mice, a suite of novel transgenic technologies designed for unmatched performance and FTO. For over 20 years, AbTherx’s passionate, innovative, and collaborative team has pushed the boundaries of antibody discovery technologies, leading to over 1,000 successful antibody discovery campaigns and 13 marketed therapeutics. AbTherx’s industry-leading team creates transformative solutions to overcome the most demanding challenges in delivering innovative medicines. Committed to making its technologies accessible to all, AbTherx offers flexible partnering models that meet the needs of drug developers of all sizes.
Key Responsibilities
- Execute antibody discovery campaigns to generate monoclonal antibodies using hybridoma and/or B-cell technology platforms, including screening, fusion, and subcloning
- Evaluate serum titer, harvest spleen and lymph nodes, and perform electrofusions
- Maintain storage and tracking of mouse tissue cell samples, hybridomas, antibody preps, etc.
- Screen and characterize antibodies for binding and functional activity using ELISA, flow cytometry, biochemical and cell-based assays, and biomolecular interaction technologies such as SPR or BLI
- Maintain, expand, cryopreserve, and clone hybridoma cell lines
- Perform small-scale antibody expression and purification of antibodies
- Explore new technologies, opportunities, and automation to improve and/or streamline the antibody discovery workflow and process
- Provide regular progress updates to the project teams and help optimize the antibody discovery workflow
Qualification Requirements
- BS in molecular biology, biochemistry, immunology, or related field with 2+ years of industry experience with strong track record of success
- Hands-on experience with antibody discovery using hybridoma technology
- Hands-on experience with somatic cloning and cryo-preservation
- Hands-on experience with protein-protein interaction using a variety of methods such as ELISA, flow cytometry, bio-layer interferometry (Octet)
- Hands-on experience with cell biology, including mammalian cell culture, transfection and running functional cell-based assays
- Hands-on experience with molecular biology techniques, including transfections, is highly desirable
- Experience with automation and high throughput assay development is highly desirable
- Highly organized with excellent attention to detail, time management, and communication skills
- Strong interpersonal and presentation skills
- Team player who is self-motivated and collaborative
Why Join AbTherx?
At AbTherx, we’re driven to create new medicines that improve human health. We are passionate about our platform’s ability to positively impact the future of medicine and recognize the vital role our team plays in shaping our science and culture.
We support our employees by providing a competitive total compensation package, including stock options, an annual performance bonus incentive program, a comprehensive benefits package, paid time off, two one-week company shutdowns each year in the summer and winter, and opportunities for professional development. We regularly hold company-wide meetings to foster open communication and a supportive community.
Join us in our dynamic startup environment where you’ll partner with colleagues of diverse backgrounds and abilities, people who contribute to all aspects of what makes our platform powerful—from technology development to drug discovery to business operations, and so much more.
AbTherx is an Equal Opportunity Employer and committed to creating an inclusive environment for all employees. We do not discriminate on the basis of race, color, religion, age, sex, creed, national origin, ancestry, citizenship status, marital or domestic or civil union status, familial status, affectional or sexual orientation, gender identity or expression, genetics, disability, military eligibility or veteran status, or any other protected status.
Primary Work Location
Foster City, CA
Apply for this job by emailing your resume to info@abtherx.com.
